Breast tenderness in women
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Date: Fri, 14 Oct 2011 |
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The new onset tenderness was much more pronounced after initiation of estrogen and progestin therapy than in women getting estrogen therapy alone. The association between new onset breast tenderness and changes in breast density also was more pronounced in the women getting the combination hormone therapy, said study first author Dr. Carolyn Crandall, a professor of general internal medicine and a scientist with UCLA's Jonsson Comprehensive Cancer Center.Multiple population studies have shown that higher breast density is associated with a higher risk of breast cancer. In women with extremely dense breasts, the cancer risk can be four to six times higher than for women whose breasts are not dense, Crandall said.
Although the present study design did not permit Crandall to directly test whether combined hormone therapy-induced breast tenderness represents increased breast cell proliferation, mammographic density is felt to be an indirect measure of breast tissue growth.The study appears this week in the early online edition of the peer-reviewed journal Breast Cancer Research and Treatment.For this prospective study, Crandall and her team examined the association between new onset breast tenderness and change in mammographic density after initiation of hormone therapy in 695 women enrolled in the Women's Health Initiative (WHI). Launched in 1991, the WHI consisted of a set of clinical trials and an observational study involving161,808 generally healthy, postmenopausal women.
Crandall looked at women on the combination therapy as well as women taking only estrogen. They analyzed the development of breast tenderness - the absence of baseline breast tenderness and the presence of tenderness at year one follow-up. They also examined change from baseline density in mammograms, measuring the percent of tissue that was dense, and density percentages from year one and two of the WHI.New breast tenderness that begins after a woman initiates therapy with routine doses of estrogen is common and almost double that of women taking a placebo," Crandall said. "It's even higher in women who also are taking a progestin, about three times higher than women given placebos."
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